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Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected.
Each subject’s T1-weighted scan was manually rigid-body realigned to Montreal Neurological Institute (MNI) template space.
Scans must have distinct intensities for grey and white matter, as well as CSF.
The intensity values, or the relative difference between intensities of each tissue type, do not influence the analysis so long as they are distinct.
In addition, a neurocognitive battery was also administered to participants in the morning (starting at AM) after breakfast and following the sleep study.
All methods were performed in accordance with the relevant guidelines and regulations.
We used a large control cohort, since increasing cohort size is one approach to improve reliability of VBM analyses in OSA.